2013.12.17 Hierarchical feedback modules and hubs of bionetworks through graph decomposition

2019-07-07 00:01:28 0

Yueheng Lan, Ph.D.

 

Assistant Professor, Department of Physics, Tsinhua University


 

 

报告时间:2013年12月17日(星期二)下午13:00-14:00

 

地点:北京大学定量生物学中心老化学楼东配楼102会议室(理教路西/光华楼北侧)

 

摘要: Through the analysis of forward and feedback links of a biochemical network based on the input-output polarity and the principle of optimal usage of resources, we are able to decompose a large network into modules. For signal transduction network,  a hierarchical structure of feedbacks is identified with local feedbacks exerting quick strong control and the global ones adjusting the dynamics in a slow and subtle way. Moreover, at the fork of forward pathways or the  intersection of the forward and  feedback edges, signaling hubs are often detected which constitute bottlenecks of the whole network.

  

主持人:刘志荣副教授