2013.1.8 Toward Modularized biological parts and Devices
(Synthetic Biology Center, Department of Biological Engineering, Massachusetts
Institute of Technology, Cambridge)
A fundamental principle of synthetic biology is modularity of genetic parts. Modularity means that these parts can be independently characterized and used to predict their combined behavior. In practice, however, the functions of genetic parts are influenced by their genetic, environmental, and cellular context. By combining quantitative measurement and computational models, I have developed a strategy to insulate transcriptional devices from their physical DNA context. This strategy has a great potential to improve the designability of larger genetic circuits and biosynthesis pathways.