2017.06.12 Understanding spatial organization of intracellular organelle networks
题 目： Understanding spatial organization of intracellular organelle networks through computational and experimental analysis
报告人：Prof. Ge Yang
Department of Biomedical Engineering & Department of Computational Biology, Carnegie Mellon University
时 间： 2017-06-12 (周一), 13:00-14:00
A basic strategy used by eukaryotic cells to organize their internal environment is to form membrane-bound organelles, which serve as biochemically distinct compartments for specialized cellular functions. Although this strategy of compartmentalization and specialization provides important structural and functional benefits, it also poses a significant challenge because specialized functions of the organelles must be coordinated and integrated for cell physiology. Cells overcome this challenge by organizing their organelles into dynamic and spatially distributed networks so that individual organelles can work together. So far, however, how intracellular organelle networks are organized remains poorly understood. In this presentation, I will focus on addressing the question of how organelle networks are spatially organized to ensure that the right organelles are at the right place at the right time. I will present results from our recent studies on the mitochondrial network in the axon of Drosophila motor neurons as well as the networks of lysosomes and endosomes in cultured non-polarized cells. By combining computational and experimental analysis, we investigated spatial organization of these networks under normal conditions, perturbations on the cytoskeleton and organelle biogenesis, as well as induced cell stress. Together, our findings provide new insights into some of the fundamental principles governing organization of the organelle networks of eukaryotic cells.
Dr. Ge Yang is an associate professor in the Department of Biomedical Engineering & Department of Computational Biology at Carnegie Mellon University. He received a dual bachelor degree in Mechanical Engineering and Electrical Engineering at Tsinghua University in 1991. After got a master degree in Mechanical Engineering at CAS in 1998, he went to prof. Bradley Nelson’s lab at University of Minnesota Twin Cities and got his PhD degree in 2004. He took a postdoc with Prof. Gaudenz Danuser in Scripps Research Institute and trained in Computational Cell Biology from 2004 to 2008.
Dr. Ge Yang’s lab pursue research and education in integrating engineering and computation strategies and technologies into biological studies to understand the mechanisms of basic cellular processes. They focus specifically on combining imaging with computation to quantitatively characterize and understand spatial-temporal cell dynamics.