2016.06.01 DECIPHERING THE STOCHASTIC KINETICS OF GENE REGULATION
题 目： DECIPHERING THE STOCHASTIC KINETICS OF GENE REGULATION
报告人： Ido Golding, Associate Professor
Baylor College of Medicine
The Center for Theoretical Biological Physics, Rice University
Gene activity is the prime mover in the living cell, driving a cell’s function at any given time. I will report on recent advances in our ability to describe the stochastic kinetics of gene regulation, achieved through the combination of single-molecule fluorescence microscopy in individual cells, novel image analysis algorithms, and theoretical modeling. We apply our approach to explore gene regulation in a number of model organisms representing a gradation of complexity: E. coli bacteria, Drosophila embryos and mouse embryonic stem cells. brought to bear on complex social phenomena, provide tractable and quantitative understanding about how humans make decisions about one another.
Ido Golding is Associate Professor in Biochemistry and Molecular Biology at the Baylor College of Medicine and the Center for Theoretical Biological Physics at Rice University. He was trained as a theoretical condensed-matter physicist and later spent five years learning the experimental arsenal of modern molecular biology.
The goal of his lab is to form a quantitative narrative for fundamental processes in the living cell. This narrative will be built upon precise measurements performed in individual cells, at the level of individual molecules and discrete events in space and time. To achieve this resolution, they are using a synthesis of approaches: classical molecular biology and biochemistry; single-cell and single-molecule fluorescence microscopy; and advanced image- and data analysis algorithms. By using simple, coarse-grained theoretical models, they try to distill their experimental findings into general principles, which can then be tested across different biological systems.