2015.6.4 CRISPR technology for genome regulation and applications

2019-07-07 00:23:27 0



题目: CRISPR technology for genome regulation and applications

报告人: Lei Stanley Qi  PhD

       Assistant Professor, Departments of Bioengineering, Chemical and Systems Biology, and Stanford ChEM-H, Stanford University



主持人:定量生物学中心,魏平 研究员


Gene circuits allow programmable activation and repression of the genome. This provides a novel and powerful for both understanding biology and disease modeling. Here I will talk about our work on repurposing the bacterial CRISPR system as a synthetic biology toolset for sequence-specific gene regulation. The CRISPR tools enable multiplexable, inducible, and high-throughput activation or repression of genes across diverse organisms. The technology also allows genome-wide perturbation of gene expression for functional genomic research. We show several applications using the basic CRISPR tools, e.g., the construction of higher-order CRISPR circuits for modulating metabolic pathways in yeast. The CRISPR technology provides a powerful approach to engineering complex genetic systems for studying gene function and genomics.


报告人简介:亓磊,2005年获清华大学物理和数学学士学位,2012年被授予加州大学生物工程系博士学位,2012-2014年担任加州大学圣弗朗西斯科分校系统生物学Faculty Fellow2014年被聘为斯坦福大学生物工程系助理教授。已在CellNat MethodPANSNat. ProtocNat. Rev. Microbiol等学术期刊上发表论文多篇,已申请8项专利,曾获中国国家优秀留学生奖和美国国家卫生研究院Early Independence Award资助。