2015.5.25.Exploring bi-directional signaling in tumor microenvironment by proteomic approaches

2019-07-07 00:22:27 0

定量生物学中心

学术报告

题目: Exploring bi-directional signaling in tumor microenvironment by proteomic approaches

报告人: 田瑞军 博士

         南方科技大学 化学系  副教授

时间:2015-5-25(周一),13:00-14:00

地点:北京大学老化学楼东配楼101报告厅

主持人:定量生物学中心,来鲁华 教授

摘要:

Cell-cell interactions are often mediated by protein molecules expressed by one cell that are recognized by specific receptors present on neighboring cells. This intercellular communication activates specific signaling pathways through the induction of dynamic posttranslational modifications such as phosphorylation and protein-protein interactions. Mass spectrometry-based proteomics have been proven to be a robust approach for characterizing dynamic protein phosphorylation and interaction on a global scale. However, proteomic studies of signaling networks under conditions with physiological cell-cell contact have been challenging. In this talk, I will present our recent development of unbiased quantitative proteomic approaches toward this end: (1) novel phosphoproteomic approach for characterizing bi-directional intercellular signaling in pancreatic tumor microenviroment; (2) combinatorial proteomic approach for studyingCD28-mediated costimulatory signaling in T cells under physiological antigen presenting cells-based stimulation. Our work established a generally applicable strategy for studying cell-cell communication and provided valuable resources for systematically understanding dysfunctional signaling networks in tumor microenvironment in a context closer to physiological condition than was previously possible.

 

   田瑞军博士于2008年在中国科学院大连化学物理研究所获得分析化学博士学位,师从邹汉法研究员,并获得中国科学院院长优秀奖和中国科学院优秀毕业生奖励。同年加入加拿大渥太华系统生物学研究所进行博士后研究,师从Daniel Figeys教授。2010年加入加拿大多伦多大学和西奈山医院Lunenfeld-Tanenbaum研究所继续博士后研究,师从Tony Pawson院士,并获得加拿大国立卫生研究院(CIHR)博士后基金资助。2014年起受聘南方科技大学化学系副教授。致力于液相色谱和质谱联用相关的方法学和应用研究,在高灵敏度和功能蛋白质组学研究等方面发展了一系列新方法,并在细胞信号转导、肿瘤微环境和干细胞定向分化等生物医学方向开展了卓有成效的应用研究。已在国际主流学术期刊上发表论文36篇,其中以通讯作者或共同通讯作者在PNAS1)和Proteomics2)上发表文章3篇,以第一作者或共同第一作者在Angew. Chem. Int. Ed.1)、Anal. Chem.1)、Mol. Cell. Proteomics2)、Proteomics2)、J. Chromatogr. A2)等上发表文章11篇,SCI他引近1000次,H-index19。曾荣获深圳市海外高层次人才“孔雀计划” B类人才(2014)、由国际蛋白质结构分析和蛋白质组学协会(IAPSAP)颁发的2012 Young Investigator Award,并在第八届世界蛋白质组学大会(HUPO)和第三届中加分析化学研讨会等做邀请和口头报告20余次。目前担任Scientific ReportsFrontiers in EndocrinologyAustin Proteomics三种国际期刊的编委会委员职务。