韩敬东

2019-07-08 00:53:58 1

韩敬东

博士生导师

电话:021-54920458
邮箱:jdhan@picb.ac.cn

实验室主页:http://www.picb.ac.cn/hanlab

1991毕业于中国药科大学获药理学学士学位
1996
年毕业于美国爱因斯坦医学院获生物医学科学专业博士学位

担任职务:

北京大学定量生物学中心研究员

北京大学-清华大学生命科学联合中心研究员

研究方向:

分子系统生物学

研究兴趣:

本课题组主要从事分子系统生物学研究工作,具体包括:
1.研究生物网络的结构、动态及其功能;
2.通过表观组学、功能基因组学及整合网络分析,寻找衰老及干细胞分化相关的关键基因,并进一步研究分子及功能作用机制;
3.探求遗传基因网络中内在的安全稳定机制。

工作经历:

2010.09-至今,中科院计算生物学重点实验室,主任.

2010.09-至今,中科院上海生科院计算生物学研究所,所长、研究员.

2005.03-2010.08,中科院遗传与发育生物学研究所,分子系统中心主任,研究员.

2002.09-2005.03,美国哈佛大学医学院,博士后.

2001.07-2002.08,美国CQOS公司,工程师.

2000.07-2001.06,美国Rare Medium公司,软件开发.

1999.01-2000.06,美国NorthStar科技公司,工程师.

1997.06-1998.12,美国洛克菲勒大学,博士后.

代表性文章:

 

 

1.       Na Sun^, Xiaoming Yu^, Fang Li^, Denghui Liu, Shengbao Suo, Weiyang Chen, Shirui Chen, Lu Song, Christopher D. Green, Joseph McDermott, Qin Shen, Naihe Jing & Jing-Dong J. Han. Inference of differentiation time for single cell transcriptomes using cell population reference data. Nature Communications. 2017 Nov 30;8(1):1856        

2.       Xinyi Wang^, Denghui Liu^, Dajian He, Shengbao Suo, Xian Xia, Xiechao He, Jing-Dong J. Han*, and Ping Zheng*. Transcriptome analyses of rhesus monkey preimplantation embryos reveal a reduced capacity for DNA double-strand break repair in primate oocytes and early embryos. Genome Research. 2017 Apr;27(4):567-579. doi: 10.1101/gr.198044.115. Epub 2017 Feb 21.

3.       Guangdun Peng^, Shengbao Suo^, Jun Chen^, Weiyang Chen, Chang Liu, Fang Yu, Ran Wang, Shirui Chen, Na Sun, Guizhong Cui, Lu Song, Patrick P.L. Tam, Jing-Dong J. Han*, Naihe Jing*. Spatial Transcriptome for the Molecular Annotation of Lineage Fates and Cell Identity in Mid-gastrula Mouse Embryo. Developmental Cell, 2016 Mar 21;36(6):681-97. doi: 10.1016/j.devcel.2016.02.020.

4.       Lei Hou, Dan Wang, Di Chen, Yi Liu, Yue Zhang, Hao Cheng, Chi Xu, Na Sun, Joseph McDermott, and William B. Mair and Jing-Dong J. Han*. A Systems Approach to Reverse Engineer Lifespan Extension by Dietary Restriction. Cell Metabolism, 2016, 8;23(3):529-40.

5.       Yi Huang, Xiaoming Yu, Na Sun, Nan Qiao, Yaqiang Cao, Jerome D. Boyd-Kirkup, Qin Shen, and Jing-Dong J Han. Single-cell level spatial gene expression in the embryonic neural differentiation niche. Genome Research. 2015 Apr;25(4):570-81.

6.       Weiyang Chen, Wei Qian, Gang Wu, Weizhong Chen, Bo Xian, Xingwei Chen, Yaqiang Cao, Christopher D Green, Fanghong Zhao, Kun Tang and Jing-Dong J. Han*, Three-dimensional human facial morphologies as robust aging markers, Cell Research, 2015, 25:574-587 (highlighted by Nature Press Release, Science News, New Scientists, The Guardian, Daily Mail, and NewsWeek, etc).

7.       Weizhong Chen, Yi Liu, Shanshan Zhu, Christopher D. Green, Gang Wei, Jing-Dong J. Han*, Improved Nucleosome Positioning Algorithm iNPS for Accurate Nucleosome Positioning from Sequencing Data, Nature Communications 2014, doi:10.1038/ncomms5909.

8.       Ming Su, Dali Han, Jerome D Boyd-Kirkup, Xiaoming Yu and Jing-Dong J Han*Evolution of Alu towards enhancers, Cell Reports, 2014, 7(2): 376-385

9.       Jin’e Li, Yi Liu, Min Liu and Jing-Dong J Han*Functional dissection of regulatory models using gene expression data of deletion mutants, PLoS Genetics, 2013, 9(9): e1003757.

10.    Wei Zhang, Yi Liu, Na Sun, Dan Wang, Jerome Boyd-Kirkup, Xiaoyang Dou, Jing-Dong J Han*, Integrating Genomic, Epigenomic and Transcriptomic Features Reveals Modular Signatures Underlying Poor Prognosis in Ovarian Cancer, Cell Reports, 2013, 4(3):542–553

11.    Yi Liu, Nan Qiao, Shanshan Zhu, Ming Su, Na Sun, Jerome Boyd-Kirkup, Jing-Dong J. Han*. A novel Bayesian network inference algorithm for integrative analysis of heterogeneous deep sequencing data. Cell Research. 2013 Mar;23(3):440-3.

12.    Zhou, B., Yang, L., Li, S.F., Huang, J.L., Chen, H.Y., Hou, L., Wang, J.B., Green, C.D., Yan, Z., Huang, X., Zhu L., Xiao H.S., Liu Y. *, and Han J.D.J. * (2012). Midlife Gene Expressions Identify Modulators of Aging through Dietary Interventions, Proc Natl Acad Sci U S A. 8;109(19):E1201-9.

13.   Jin, C., Li, J., Green, C.D., Yu, X. , Tang, X, Han, D., Xian, Bo., Wang, D, Huang, X., Cao, X., Yan. Z., Hou, L., Liu, J., Shukeir, N., Khaitovich, P., Chen, C.D., Zhang, H., Jenuwein, T. and  Han, J.-D.J *, Histone Demethylase UTX-1 Regulates C. elegans Lifespan by Targeting Insulin/IGF-1 Signaling Pathway, Cell Metabolism, 2011, 14: 16

 

获奖情况:

·      2016年, Faculty 1000

·       2015年,上海市领军人才

·       2014年,国家百千万人才工程,并获得国家“有突出贡献中青年专家”荣誉称号

·       2011年,上海市学术带头人

·       2009年,百人计划终期评估优秀

·       2006年,国家自然科学基金委员会杰出青年基金


·       2005年,中科院百人计划