School of Life Sciences, Center for Quantitative Biology, Center for Life Sciences, PKU
B.S., Microbiology, Nankai University, 2002
Ph.D., Physical Chemistry, Peking University, 2007
12/2009 – 06/2013 Postdoctoral fellow, HHMI/UCSF
07/2007 – 12/2009 UCSF-PKU Joint Postdoctoral Fellow, UCSF
Our research interests are using newly emerging discipline of synthetic biology to rethink about and reprogram important cellular signaling transduction networks. We will focus on developing synthetic biology toolbox and use synthetic biology approach to understand how the signaling network topology correlate to specific signaling dynamics, and how the spatial, temporal and quantitative changes of signaling dynamics determine cell-fate. We want to introduce these basic network design principles to engineer therapeutic cells to benefit cancer therapy.
1. Zhang, Z., Wang, Q., Ke, Y., Liu, S., Ju, J., Lim, A.W., Tang, C., Wei, P.*, Design of Tunable Oscillatory Dynamics in a Synthetic NF-κB Signaling Circuit, Cell Systems 2017, 5, 460-470.
2. Mitchell, A., Wei, P.*, Lim, A.W.*, Oscillatory stress stimulation uncovers an Achilles’ heel of the yeast MAPK signaling network. Science 2015; 350, 1379-1383. (*co-corr. author)
3. Wei, P.*, Wong, W.W.*, Park, J.S., Corcoran, E. E., Peisajovich, S. G., Onuffer, J, J., Weiss, A., Lim, W.A. Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature 2012; 488, 384-388.
4. Peisajovich, S.G., Garbarino, J.E., Wei, P., Lim, W.A. Rapid diversification of cell signaling phenotypes by modular domain recombination. Science 2010; 328, 368-372